Issue 47, 2010
From the journal:

Chemical Communications

Photochemical cleavage of leader peptides†‡

Noah Bindman,a   Remco Merkx,a   Robert Koehler,a   Nicholas Herrmana  and  Wilfred A. van der Donk*a  

* Corresponding authors

a Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, 600 S Mathews Ave, Urbana, USA
E-mail: vddonk@uiuc.edu
Fax: +1 217 244-8533
Tel: +1 217 244-5360

Abstract

We report a photolabile linker compatible with Fmoc solid phase peptide synthesis and Cu(I)-catalyzed alkyne–azide cycloaddition that allows photochemical cleavage to afford a C-terminal peptide fragment with a native amino terminus.

Graphical abstract: Photochemical cleavage of leader peptides

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Article information

DOI
https://doi.org/10.1039/C0CC02945A
Article type
Communication
Submitted
01 Aug 2010
Accepted
14 Oct 2010
First published
02 Nov 2010

Chem. Commun., 2010,46, 8935-8937

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Photochemical cleavage of leader peptides

N. Bindman, R. Merkx, R. Koehler, N. Herrman and W. A. van der Donk, Chem. Commun., 2010, 46, 8935 DOI: 10.1039/C0CC02945A

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