Issue 43, 2010

A practical solution-phase synthesis of an antagonistic peptide of TNF-α based on hydrophobic tag strategy

Abstract

A simple acid-resistant hydrophobic tag, which can be removed rapidly in a single-step procedure after overall peptide synthesis, has been developed to accomplish practical solution-phase synthesis of a 15-mer antagonistic peptide of TNF-α (A-TNF-α). Hydrophobically tagged peptides can be separated as precipitates at each step by addition of a polar organic solvent.

Graphical abstract: A practical solution-phase synthesis of an antagonistic peptide of TNF-α based on hydrophobic tag strategy

Supplementary files

Article information

Article type
Communication
Submitted
06 Aug 2010
Accepted
07 Sep 2010
First published
30 Sep 2010

Chem. Commun., 2010,46, 8219-8221

A practical solution-phase synthesis of an antagonistic peptide of TNF-α based on hydrophobic tag strategy

G. Tana, S. Kitada, S. Fujita, Y. Okada, S. Kim and K. Chiba, Chem. Commun., 2010, 46, 8219 DOI: 10.1039/C0CC03090B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements