Issue 43, 2010
From the journal:

Chemical Communications

Enhancement of antimicrobial activity by synthetic ion channel synergy

Jason L. Atkins,a   Mohit B. Patel,a   Zachary Cusumanob  and  George W. Gokel*ab  

* Corresponding authors

a Departments of Chemistry & Biochemistry and Biology, Center for Nanoscience, University of Missouri–Saint Louis, Saint Louis, USA
E-mail: gokelg@umsl.edu

b Washington University School of Medicine, St. Louis, USA

Abstract

Hydraphile synthetic ion channels were found to enhance the cytotoxicity to E. coli and B. subtilis of erythromycin, kanamycin, rifampicin, and tetracycline when co-administered with the antibiotic at sublethal concentrations of channel.

Graphical abstract: Enhancement of antimicrobial activity by synthetic ion channel synergy

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Article information

DOI
https://doi.org/10.1039/C0CC03138K
Article type
Communication
Submitted
09 Aug 2010
Accepted
24 Sep 2010
First published
08 Oct 2010

Chem. Commun., 2010,46, 8166-8167

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Enhancement of antimicrobial activity by synthetic ion channel synergy

J. L. Atkins, M. B. Patel, Z. Cusumano and G. W. Gokel, Chem. Commun., 2010, 46, 8166 DOI: 10.1039/C0CC03138K

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