Issue 48, 2010
From the journal:

Chemical Communications

Analysis of the dispersity in carbohydrate loading of synthetic glycoproteins using MALDI-TOF mass spectrometry†

Mitul K. Patel,a   Balakumar Vijayakrishnan,a   Julia R. Koeppe,a   Justin M. Chalker,a   Katie J. Dooresa  and  Benjamin G. Davis*a  

* Corresponding authors

a Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, UK
E-mail: Ben.Davis@chem.ox.ac.uk
Fax: +44 (0)1865 285002
Tel: +44 (0)1865 285001

Abstract

Statistical correlation of mass spectrum peak broadening with product dispersity in protein conjugation reactions allows more detailed characterization of putative therapeutic conjugates.

Graphical abstract: Analysis of the dispersity in carbohydrate loading of synthetic glycoproteins using MALDI-TOF mass spectrometry

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Article information

DOI
https://doi.org/10.1039/C0CC03420G
Article type
Communication
Submitted
23 Aug 2010
Accepted
29 Sep 2010
First published
29 Oct 2010

Chem. Commun., 2010,46, 9119-9121

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Analysis of the dispersity in carbohydrate loading of synthetic glycoproteins using MALDI-TOF mass spectrometry

M. K. Patel, B. Vijayakrishnan, J. R. Koeppe, J. M. Chalker, K. J. Doores and B. G. Davis, Chem. Commun., 2010, 46, 9119 DOI: 10.1039/C0CC03420G

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