Issue 48, 2010
From the journal:

Chemical Communications

Transcutaneous immunization by a solid-in-oil nanodispersion†‡

Yoshiro Tahara,a   Kenichi Namatsu,a   Noriho Kamiya,ab   Masayori Hagimori,c   Seitaro Kamiya,c   Masayuki Arakawac  and  Masahiro Goto*abd  

* Corresponding authors

a Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Moto-oka, Fukuoka 819-0395, Japan

b Center for Future Chemistry, Kyushu University, 744 Moto-oka, Fukuoka 819-0395, Japan
E-mail: m-goto@mail.cstm.kyushu-u.ac.jp
Fax: +81 92-802-2810
Tel: +81 92-802-2806

c Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo, Japan

d SO Pharmaceutical Corporation, 1-5-2 Minatojima-minamimachi, Kobe 650-0047, Japan

Abstract

We have successfully achieved transcutaneous immunization without the use of any skin pre-treatment or immune-stimulant adjuvant by applying a solid-in-oil (S/O) nanodispersion: an oil-based nanodispersion of antigens coated with hydrophobic surfactant molecules. This finding indicates that the S/O nanodispersion has great promise for effective transcutaneous vaccination.

Graphical abstract: Transcutaneous immunization by a solid-in-oil nanodispersion

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Article information

DOI
https://doi.org/10.1039/C0CC03600E
Article type
Communication
Submitted
01 Sep 2010
Accepted
08 Oct 2010
First published
28 Oct 2010

Chem. Commun., 2010,46, 9200-9202

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Transcutaneous immunization by a solid-in-oil nanodispersion

Y. Tahara, K. Namatsu, N. Kamiya, M. Hagimori, S. Kamiya, M. Arakawa and M. Goto, Chem. Commun., 2010, 46, 9200 DOI: 10.1039/C0CC03600E

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