Issue 46, 2010
From the journal:

Chemical Communications

Iron-catalyzed synthesis of glycine derivativesviacarbon–nitrogen bond cleavage using diazoacetate†

Yoichiro Kuninobu,*a   Mitsumi Nishia  and  Kazuhiko Takai*a  

* Corresponding authors

a Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University, Tsushima, Kita-ku, Okayama 700-8530, Japan
E-mail: kuninobu@cc.okayama-u.ac.jp, ktakai@cc.okayama-u.ac.jp
Fax: +81 (0)86-251-8094
Tel: +81 (0)86-251-8095

Abstract

Treatment of tertiary amines with diazoacetate in the presence of a catalytic amount of an iron salt, FeCl3, in ethanol gave glycine derivatives. In this reaction, a carbon–nitrogen single bond of the amine was cleaved.

Graphical abstract: Iron-catalyzed synthesis of glycine derivatives via carbon–nitrogen bond cleavage using diazoacetate

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Article information

DOI
https://doi.org/10.1039/C0CC03781H
Article type
Communication
Submitted
10 Sep 2010
Accepted
01 Oct 2010
First published
21 Oct 2010

Chem. Commun., 2010,46, 8860-8862

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Iron-catalyzed synthesis of glycine derivatives via carbon–nitrogen bond cleavage using diazoacetate

Y. Kuninobu, M. Nishi and K. Takai, Chem. Commun., 2010, 46, 8860 DOI: 10.1039/C0CC03781H

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