Issue 47, 2010
From the journal:

Chemical Communications

Sustained release of nucleic acids from polymeric nanoparticles using microemulsion precipitation in supercritical carbon dioxide

Jun Ge,a   Gunilla B. Jacobson,a   Tatsiana Lobovkina,a   Krister Holmbergb  and  Richard N. Zare*a  

* Corresponding authors

a Department of Chemistry, Stanford University, 333 Campus Drive, Stanford, USA
E-mail: zare@stanford.edu
Fax: +1 650-725-0259

b Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-412 96 Göteborg, Sweden

Abstract

A general approach for producing biodegradable nanoparticles for sustained nucleic acid release is presented. The nanoparticles are produced by precipitating a water-in-oil microemulsion in supercritical CO2. The microemulsion consists of a transfer RNA aqueous solution (water phase), dichloromethane containing poly(L-lactic acid)–poly(ethylene glycol) (oil phase), the surfactant n-octyl β-D-glucopyranoside, and the cosurfactant n-butanol.

Graphical abstract: Sustained release of nucleic acids from polymeric nanoparticles using microemulsion precipitation in supercritical carbon dioxide

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Article information

DOI
https://doi.org/10.1039/C0CC04258G
Article type
Communication
Submitted
06 Oct 2010
Accepted
15 Oct 2010
First published
04 Nov 2010

Chem. Commun., 2010,46, 9034-9036

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Sustained release of nucleic acids from polymeric nanoparticles using microemulsion precipitation in supercritical carbon dioxide

J. Ge, G. B. Jacobson, T. Lobovkina, K. Holmberg and R. N. Zare, Chem. Commun., 2010, 46, 9034 DOI: 10.1039/C0CC04258G

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