Issue 5, 2010

Markedly different cytotoxicity of the two enantiomers of C2-symmetrical Ti(iv) phenolato complexes; mechanistic implications

Abstract

The two enantiomers of a member of the highly active C2-symmetrical bis(isopropoxo) Ti(IV) family of complexes of diamine bis(phenolato) ligands demonstrate markedly different cytotoxicity, supporting a chiral biological target of activity and participation of a ligand-bound active species.

Graphical abstract: Markedly different cytotoxicity of the two enantiomers of C2-symmetrical Ti(iv) phenolato complexes; mechanistic implications

Supplementary files

Article information

Article type
Communication
Submitted
29 Jun 2009
Accepted
16 Oct 2009
First published
02 Nov 2009

Dalton Trans., 2010,39, 1182-1184

Markedly different cytotoxicity of the two enantiomers of C2-symmetrical Ti(IV) phenolato complexes; mechanistic implications

C. M. Manna and E. Y. Tshuva, Dalton Trans., 2010, 39, 1182 DOI: 10.1039/B920786B

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