The coordination abilities of tetrapeptides containing β-amino acids towards Cu(II) ions are presented. The studied tetrapeptides were: Ac-βAlaHisGlyHis, βAlaHisGlyHis, Ac-βAspHisGlyHis, βAspHisGlyHis, Ac-βAspHisGly-DHis and βAspHisGly-DHis. Thorough potentiometric titrations were carried out to establish the stoichiometry of the resulting metal–ligand complexes and the role of free -αCOO− side chain group in metal binding. The copper(II) coordination mode of the complexes was investigated by performing detailed spectroscopic analyses (UV-Vis, EPR, CD) in strict correlation with potentiometric measurements.
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