Issue 35, 2010

Differences between the macroscopic and tracer level chemistry of rhenium and technetium: contrasting cage isomerisation behaviour of Re(i) and Tc(i) carborane complexes

Abstract

Carboranes form stable complexes with the [M(CO)3]+ (M = 99mTc, Re) core and are viable ligands for the development of targeted radiopharmaceuticals. 99mTc-carborane complexes were found to exhibit substantially different 1,2→1,7 cage isomerisation behaviour than their Re counterparts, challenging the validity of the routine use of rhenium as a surrogate for the development of technetium-99m based molecular imaging agents.

Graphical abstract: Differences between the macroscopic and tracer level chemistry of rhenium and technetium: contrasting cage isomerisation behaviour of Re(i) and Tc(i) carborane complexes

Supplementary files

Article information

Article type
Communication
Submitted
17 May 2010
Accepted
23 Jul 2010
First published
09 Aug 2010

Dalton Trans., 2010,39, 8128-8131

Differences between the macroscopic and tracer level chemistry of rhenium and technetium: contrasting cage isomerisation behaviour of Re(I) and Tc(I) carborane complexes

A. F. Armstrong and J. F. Valliant, Dalton Trans., 2010, 39, 8128 DOI: 10.1039/C0DT00490A

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