Issue 12, 2010

2-Azetidinones: synthesis of new bis(indolyl)butyl-β-lactams

Abstract

New β-lactam compounds containing a bis(indolyl)-framework were synthesized. The key step in the synthetic strategy was a nucleophilic addition of unprotected indole to a suitable butyl aldehyde anchored on the C-4 side chain of azetidinone intermediates. The use of an ionic liquid as reaction medium allowed the use of a catalytic amount of Dy(OTf)3 for the nucleophilic addition and facilitated the isolation of the product.

Graphical abstract: 2-Azetidinones: synthesis of new bis(indolyl)butyl-β-lactams

Article information

Article type
Paper
Submitted
15 Jun 2010
Accepted
05 Aug 2010
First published
02 Sep 2010

New J. Chem., 2010,34, 2861-2866

2-Azetidinones: synthesis of new bis(indolyl)butyl-β-lactams

P. Galletti, A. Quintavalla, C. Ventrici, G. Giannini, W. Cabri and D. Giacomini, New J. Chem., 2010, 34, 2861 DOI: 10.1039/C0NJ00463D

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