Issue 5, 2010
From the journal:

Organic & Biomolecular Chemistry

A new facile synthesis of 3-amidoindole derivatives and their evaluation as potential GSK-3βinhibitors†

Anahit Pews-Davtyan,a   Annegret Tillack,a   Anne-Caroline Schmöle,b   Stefanie Ortinau,b   Moritz J. Frech,b   Arndt Rolfs*b  and  Matthias Beller*a  

* Corresponding authors

a Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, Rostock, Germany
E-mail: matthias.beller@catalysis.de
Fax: +49 381 1281 51113
Tel: +49 381 1281 113

b Albrecht-Kossel-Institute for Neuroregeneration, Center for Mental Health Disease, University of Rostock, Gehlsheimerstr. 20, Rostock, Germany
E-mail: arndt.rolfs@med.uni-rostock.de
Fax: +49 381 494 4699
Tel: +49 381 494 9540

Abstract

3-Amidoindoles were synthesized from commercially available arylhydrazines and propargylamines over Zn-salt mediated one pot procedure in excellent regioselectivity and up to 94% yield.

Graphical abstract: A new facile synthesis of 3-amidoindole derivatives and their evaluation as potential GSK-3β inhibitors

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Article information

DOI
https://doi.org/10.1039/B920861E
Article type
Paper
Submitted
06 Oct 2009
Accepted
27 Nov 2009
First published
14 Jan 2010

Org. Biomol. Chem., 2010,8, 1149-1153

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A new facile synthesis of 3-amidoindole derivatives and their evaluation as potential GSK-3β inhibitors

A. Pews-Davtyan, A. Tillack, A. Schmöle, S. Ortinau, M. J. Frech, A. Rolfs and M. Beller, Org. Biomol. Chem., 2010, 8, 1149 DOI: 10.1039/B920861E

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