Issue 22, 2010
From the journal:

Organic & Biomolecular Chemistry

Application of click–click chemistry to the synthesis of new multivalent RGD conjugates†

Mathieu Galibert,a   Lucie Sancey,b   Olivier Renaudet,a   Jean-Luc Coll,b   Pascal Dumya  and  Didier Boturyn*a  

* Corresponding authors

a Département de Chimie Moléculaire, UMR CNRS/UJF 5250, ICMG FR 2607, 570 rue de la chimie, BP 53, France
E-mail: didier.boturyn@ujf-grenoble.fr
Fax: + 33 4 56 52 08 05
Tel: + 33 4 56 52 08 32

b Institut Albert Bonniot, INSERM U823, BP 170, France

Abstract

New multivalent RGD-containing macromolecules were designed by exploiting two orthogonal chemoselective ligations. They were next applied to a competitive cell adhesion assay and used for the non invasive optical imaging of tumour in small animals.

Graphical abstract: Application of click–click chemistry to the synthesis of new multivalent RGD conjugates

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Article information

DOI
https://doi.org/10.1039/C0OB00070A
Article type
Paper
Submitted
30 Apr 2010
Accepted
20 Jul 2010
First published
09 Sep 2010

Org. Biomol. Chem., 2010,8, 5133-5138

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Application of click–click chemistry to the synthesis of new multivalent RGD conjugates

M. Galibert, L. Sancey, O. Renaudet, J. Coll, P. Dumy and D. Boturyn, Org. Biomol. Chem., 2010, 8, 5133 DOI: 10.1039/C0OB00070A

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