An enantioselective total synthesis of natural antibiotic marasin

Abstract

Synthetic studies directed toward the allenediyne antibiotic marasin are presented. Different approaches to the installation of the optically active chiral allenediyne motif were explored en route to the synthesis of the natural product. The stereoselectivity for the construction of the chiral allenediyne motif was dependent on not only the reaction employed but also the substrate structure.