Issue 1, 2010
From the journal:

Chemical Science

Cell surface-based differentiation of cell types and cancer states using a gold nanoparticle-GFP based sensing array†

Avinash Bajaj,a   Subinoy Rana,a   Oscar R. Miranda,a   Joseph C. Yawe,a   D. Joseph Jerry,b   Uwe H. F. Bunzc  and  Vincent M. Rotello*a  

* Corresponding authors

a Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, USA
E-mail: rotello@chem.umass.edu
Fax: (+1)413-5452058

b Department of Veterinary and Animal Science, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, USA

c School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, USA

Abstract

Gold nanoparticle-green fluorescent protein (NP-GFP) based arrays have been created for rapid identification of mammalian cells on the basis of cell surface properties. Highly reproducible characteristic patterns were obtained from different cell types enabling the identification of cell types and cancer states. Using these arrays we could differentiate between isogenic normal, cancer and metastatic cell types using only ∼5000 cells.

Graphical abstract: Cell surface-based differentiation of cell types and cancer states using a gold nanoparticle-GFP based sensing array

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Article information

DOI
https://doi.org/10.1039/C0SC00165A
Article type
Edge Article
Submitted
03 Feb 2010
Accepted
29 Mar 2010
First published
24 May 2010

Chem. Sci., 2010,1, 134-138

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Cell surface-based differentiation of cell types and cancer states using a gold nanoparticle-GFP based sensing array

A. Bajaj, S. Rana, O. R. Miranda, J. C. Yawe, D. J. Jerry, U. H. F. Bunz and V. M. Rotello, Chem. Sci., 2010, 1, 134 DOI: 10.1039/C0SC00165A

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