Issue 15, 2011

Direct analysis of camptothecin from Nothapodytes nimmoniana by desorption electrospray ionizationmass spectrometry (DESI-MS)

Abstract

Desorption electrospray ionization was employed for fast and direct ambient detection of the anti-tumor drug, camptothecin, and its derivative, 9-methoxycamptothecin in Nothapodytes nimmoniana. Different parts of the plant such as leaves, stems and bark were examined. The ion intensities suggest that the concentration in bark is higher than that in the leaves and stems. The method does not require any sample preparation or preseparation. The identity of the alkaloids was further confirmed by tandem mass spectrometry.

Graphical abstract: Direct analysis of camptothecin from Nothapodytes nimmoniana by desorption electrospray ionization mass spectrometry (DESI-MS)

Article information

Article type
Communication
Submitted
21 Apr 2011
Accepted
02 Jun 2011
First published
21 Jun 2011

Analyst, 2011,136, 3066-3068

Direct analysis of camptothecin from Nothapodytes nimmoniana by desorption electrospray ionization mass spectrometry (DESI-MS)

A. Srimany, D. R. Ifa, H. R. Naik, V. Bhat, R. G. Cooks and T. Pradeep, Analyst, 2011, 136, 3066 DOI: 10.1039/C1AN15339K

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