Issue 22, 2011

A novel microreactor approach for analysis of ketones and aldehydes in breath

Abstract

We report a fabricated microreactor with thousands of micropillars in channels. Each micropillar surface is chemically functionalized to selectively preconcentrate gaseous ketones and aldehydes of exhaled breath and to enhance ultra-trace, rapid analysis by direct-infusion Fourier transform-ion cyclotron resonance (FT-ICR) mass spectrometry (MS). The micropillar reactive coating contains the quaternary ammonium aminooxy salt 2-(aminooxy)ethyl-N,N,N-trimethylammonium iodide (ATM) for capturing trace carbonyl VOCs by means of an oximation reaction. We demonstrate the utility of this approach for detection of C1 to C12aldehydes and ketones in exhaled breath, but the approach is applicable to any gaseous sample.

Graphical abstract: A novel microreactor approach for analysis of ketones and aldehydes in breath

Article information

Article type
Communication
Submitted
19 Jul 2011
Accepted
19 Aug 2011
First published
06 Sep 2011

Analyst, 2011,136, 4662-4666

A novel microreactor approach for analysis of ketones and aldehydes in breath

X. Fu, M. Li, S. Biswas, M. H. Nantz and R. M. Higashi, Analyst, 2011, 136, 4662 DOI: 10.1039/C1AN15618G

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