Issue 1, 2011

An efficient oxidative dearomatization–radical cyclization approach to symmetrically substituted bicyclic guttiferone natural products

Abstract

Detailed in this communication is an efficient synthetic approach towards the guttiferone family of natural products. Oxidatively unraveling a para-quinone monoketal followed by consecutive 5-exo radical cyclizations provides the bicyclic core. An additional strength of this approach is a late stage asymmetric desymmetrization of an advanced symmetric intermediate.

Graphical abstract: An efficient oxidative dearomatization–radical cyclization approach to symmetrically substituted bicyclic guttiferone natural products

Supplementary files

Article information

Article type
Communication
Submitted
14 May 2010
Accepted
18 Jun 2010
First published
07 Jul 2010

Chem. Commun., 2011,47, 209-211

An efficient oxidative dearomatization–radical cyclization approach to symmetrically substituted bicyclic guttiferone natural products

N. A. McGrath, J. R. Binner, G. Markopoulos, M. Brichacek and J. T. Njardarson, Chem. Commun., 2011, 47, 209 DOI: 10.1039/C0CC01419B

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