Issue 1, 2011
From the journal:

Chemical Communications

The pattern recognition molecule deleted in malignant brain tumors 1 (DMBT1) and synthetic mimics inhibit liposomal nucleic acid delivery†

Pernille Lund Hansen,‡ab   Stephanie Blaich,‡c   Caroline End,d   Steffen Schmidt,ab   Jesper B. Moeller,e   Uffe Holmskove  and  Jan Mollenhauer*ab  

* Corresponding authors

a Lundbeckfonden Center of Excellence NanoCAN, University of Southern Denmark, 5000 Odense C, Denmark
E-mail: jmollenhauer@health.sdu.dk

b Molecular Oncology Group, University of Southern Denmark, 5000 Odense C, Denmark

c Unit Cancer Genome Research, Division of Molecular Genetics, Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany

d Division of Molecular Genome Analysis, Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany

e Cardiovascular and Renal Research, University of Southern Denmark, 5000 Odense C, Denmark

Abstract

Liposomal nucleic acid delivery is a preferred option for therapeutic settings. The cellular pattern recognition molecule DMBT1, secreted at high levels in various diseases, and synthetic mimics efficiently inhibit liposomal nucleic acid delivery to human cells. These findings may have relevance for therapeutic nucleic acid delivery strategies.

Graphical abstract: The pattern recognition molecule deleted in malignant brain tumors 1 (DMBT1) and synthetic mimics inhibit liposomal nucleic acid delivery

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Article information

DOI
https://doi.org/10.1039/C0CC02186E
Article type
Communication
Submitted
29 Jun 2010
Accepted
18 Aug 2010
First published
07 Sep 2010

Chem. Commun., 2011,47, 188-190

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The pattern recognition molecule deleted in malignant brain tumors 1 (DMBT1) and synthetic mimics inhibit liposomal nucleic acid delivery

P. Lund Hansen, S. Blaich, C. End, S. Schmidt, J. B. Moeller, U. Holmskov and J. Mollenhauer, Chem. Commun., 2011, 47, 188 DOI: 10.1039/C0CC02186E

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