Issue 1, 2011
From the journal:

Chemical Communications

Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity†

Anthony S. Breitbach,‡a   Adam H. Broderick,‡b   Christopher M. Jewell,b   Suvai Gunasekaran,b   Qi Lin,a   David M. Lynn*ab  and  Helen E. Blackwell*a  

* Corresponding authors

a Department of Chemistry, University of Wisconsin-Madison, 1101 University Ave., Madison, USA
E-mail: blackwell@chem.wisc.edu

b Department of Chemical and Biological Engineering, University of Wisconsin-Madison, 1415 Engineering Drive, Madison, USA
E-mail: dlynn@engr.wisc.edu

Abstract

We demonstrate an approach to the surface-mediated release of a synthetic N-acylated L-homoserine lactone (AHL) modulator of bacterial quorum sensing (QS). AHL released gradually from thin films of poly(lactide-co-glycolide) (PLG) is shown to activate QS in the model symbiont Vibrio fischeri at levels that exceed those promoted by direct solution-based administration.

Graphical abstract: Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity

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Article information

DOI
https://doi.org/10.1039/C0CC02316G
Article type
Communication
Submitted
01 Jul 2010
Accepted
13 Aug 2010
First published
09 Sep 2010

Chem. Commun., 2011,47, 370-372

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Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity

A. S. Breitbach, A. H. Broderick, C. M. Jewell, S. Gunasekaran, Q. Lin, D. M. Lynn and H. E. Blackwell, Chem. Commun., 2011, 47, 370 DOI: 10.1039/C0CC02316G

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