Issue 10, 2011
From the journal:

Chemical Communications

Bio-functionalization of metal–organic frameworks by covalent protein conjugation†

Suhyun Jung,a   Youngmee Kim,b   Sung-Jin Kim,b   Tae-Hwan Kwon,c   Seong Huh*c  and  Seongsoon Park*a  

* Corresponding authors

a Department of Chemistry, Center for NanoBio Applied Technology, Institute of Basic Sciences, Sungshin Women's University, Seoul 136-742, Korea
E-mail: spark@sungshin.ac.kr
Fax: +82 2 920 2047
Tel: +82 2 920 7646

b Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Korea

c Department of Chemistry and Protein Research Center for Bio-Industry, Hankuk University of Foreign Studies, Yongin 449-791, Korea
E-mail: shuh@hufs.ac.kr

Abstract

Bioconjugation of functional proteins onto metal–organic frameworks (MOFs) has been achieved using activation of pendent linking groups of the organic linkers on the surface of MOFs. Fluorescent microscopy revealed successful conjugation of an enhanced fluorescent protein onto MOFs. In addition, Candida-antarctica-lipase-B-conjugated MOFs showed no loss of enantioselectivity and activity in transesterification of (±)-1-phenylethanol.

Graphical abstract: Bio-functionalization of metal–organic frameworks by covalent protein conjugation

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Article information

DOI
https://doi.org/10.1039/C0CC03288C
Article type
Communication
Submitted
16 Aug 2010
Accepted
17 Dec 2010
First published
17 Jan 2011

Chem. Commun., 2011,47, 2904-2906

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Bio-functionalization of metal–organic frameworks by covalent protein conjugation

S. Jung, Y. Kim, S. Kim, T. Kwon, S. Huh and S. Park, Chem. Commun., 2011, 47, 2904 DOI: 10.1039/C0CC03288C

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