Issue 2, 2011

Oxygen catalyzed mobilization of iron from ferritin by iron(iii) chelate ligands

Abstract

Tridentate chelate ligands of 2,6-bis[hydroxy(methyl)amino]-1,3,5-triazine family rapidly release iron from human recombinant ferritin in the presence of oxygen. The reaction is inhibited by superoxide dismutase, catalase, mannitol and urea. Suggested reaction mechanism involves reduction of the ferritin iron core by superoxide anion, diffusion of iron(II) cations outside the ferritin shell, and regeneration of superoxide anions through oxidation of iron(II) chelate complexes with molecular oxygen.

Graphical abstract: Oxygen catalyzed mobilization of iron from ferritin by iron(iii) chelate ligands

Supplementary files

Article information

Article type
Communication
Submitted
24 Aug 2010
Accepted
18 Oct 2010
First published
08 Nov 2010

Chem. Commun., 2011,47, 731-733

Oxygen catalyzed mobilization of iron from ferritin by iron(III) chelate ligands

F. Bou-Abdallah, J. McNally, X. X. Liu and A. Melman, Chem. Commun., 2011, 47, 731 DOI: 10.1039/C0CC03454A

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