A novel pH-responsive polysaccharidic ionic complex for proapoptotic D-(KLAKLAK)2 peptide delivery

Bo Reum Lee; Kyung Taek Oh; Young Taik Oh; Hye Jung Baik; So Young Park; Yu Seok Youn; Eun Seong Lee

doi:10.1039/C0CC03590D

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

A novel pH-responsive polysaccharidic ionic complex for proapoptotic d-(KLAKLAK)₂peptide delivery†

Bo Reum Lee,‡^a Kyung Taek Oh,‡^b Young Taik Oh,^c Hye Jung Baik,^a So Young Park,^a Yu Seok Youn^d and Eun Seong Lee*^a

Author affiliations

* Corresponding authors

^a Division of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon, Gyeonggi-do 420-743, Republic of Korea
E-mail: eslee@catholic.ac.kr

^b College of Pharmacy, Chung-Ang University, 221 Heukseok dong, Dongjak-gu, Seoul 155-756, Republic of Korea

^c Department of Diagnostic Radiology, Yonsei University College of Medicine, Seodaemun-ku Shinchon-dong 134, Seoul, Republic of Korea

^d College of Pharmacy, Pusan National University, Jangjun-dong, Geumjeong-gu, Busan 609-735, Republic of Korea

Abstract

We report charge-switching ionic nanocomplexes comprised of glycol chitosan grafted with 2,3-dimethylmaleic acid (DMA) (denoted as ‘GCS-g-DMA’ hereafter) and a proapoptotic peptide. This system allowed for improved peptide delivery to tumor sites via a mechanism of selective peptide release when the pH was dropped from 7.4 to 6.8.

Download options Please wait...

Supplementary files

Supplementary information PDF (1762K)

Article information

DOI: https://doi.org/10.1039/C0CC03590D
Article type: Communication
Submitted: 01 Sep 2010
Accepted: 31 Jan 2011
First published: 14 Feb 2011

Download Citation

Chem. Commun., 2011,47, 3852-3854

Permissions

Request permissions

A novel pH-responsive polysaccharidic ionic complex for proapoptotic D-(KLAKLAK)₂ peptide delivery

B. R. Lee, K. T. Oh, Y. T. Oh, H. J. Baik, S. Y. Park, Y. S. Youn and E. S. Lee, Chem. Commun., 2011, 47, 3852 DOI: 10.1039/C0CC03590D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications