Issue 2, 2011
From the journal:

Chemical Communications

Iron-catalyzed synthesis of polysubstituted pyrrolesvia [4C+1N] cyclization of 4-acetylenic ketones with primary amines†‡

Yeming Wang,a   Xihe Bi,*a   Dehua Li,a   Peiqiu Liao,a   Yidong Wang,a   Jin Yang,a   Qian Zhang*a  and  Qun Liua  

* Corresponding authors

a Department of Chemistry, Northeast Normal University, 5268 Renmin Street, 130024 Changchun, China
E-mail: bixh507@nenu.edu.cn, zhangq651@nenu.edu.cn

Abstract

A highly efficient iron-catalyzed approach to polysubstituted pyrroles has been developed through the [4C+1N] cyclization of 4-acetylenic ketones with primary amines, leading to the synthesis of a variety of tetra- and fully-substituted pyrroles as well as fused pyrrole derivatives in good to excellent yields.

Graphical abstract: Iron-catalyzed synthesis of polysubstituted pyrrolesvia [4C+1N] cyclization of 4-acetylenic ketones with primary amines

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Article information

DOI
https://doi.org/10.1039/C0CC03802D
Article type
Communication
Submitted
11 Sep 2010
Accepted
14 Oct 2010
First published
11 Nov 2010

Chem. Commun., 2011,47, 809-811

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Iron-catalyzed synthesis of polysubstituted pyrrolesvia [4C+1N] cyclization of 4-acetylenic ketones with primary amines

Y. Wang, X. Bi, D. Li, P. Liao, Y. Wang, J. Yang, Q. Zhang and Q. Liu, Chem. Commun., 2011, 47, 809 DOI: 10.1039/C0CC03802D

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