Issue 9, 2011

Solid phase strain promoted “click” modification of DNAvia[3+2]-nitrile oxide–cyclooctyne cycloadditions

Abstract

Rapid, catalyst free, solid phase modification of DNA by strain promoted cyclooctynenitrile oxide click chemistry is reported; the reaction is characterised by mild conditions, occurring in an aqueous environment under atmospheric conditions at room temperature and is complete in 10 minutes.

Graphical abstract: Solid phase strain promoted “click” modification of DNAvia[3+2]-nitrile oxide–cyclooctyne cycloadditions

Supplementary files

Article information

Article type
Communication
Submitted
20 Sep 2010
Accepted
30 Nov 2010
First published
21 Dec 2010

Chem. Commun., 2011,47, 2706-2708

Solid phase strain promoted “click” modification of DNAvia[3+2]-nitrile oxide–cyclooctyne cycloadditions

I. Singh and F. Heaney, Chem. Commun., 2011, 47, 2706 DOI: 10.1039/C0CC03985C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements