Issue 13, 2011
From the journal:

Chemical Communications

A sensitive and selective resonance light scattering bioassay for homocysteine in biological fluids based on target-involved assembly of polyethyleneimine-capped Ag-nanoclusters†

Shao-Kai Sun,a   He-Fang Wanga  and  Xiu-Ping Yan*a  

* Corresponding authors

a Research Center for Analytical Sciences, and Key Laboratory of Functional Polymer Materials, Ministry of Education, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, China
E-mail: xpyan@nankai.edu.cn
Fax: +86 22-23506075
Tel: +86 22-23504605

Abstract

A specific resonance light scattering bioassay for homocysteine is developed on the basis of target-involved assembly of polyethyleneimine-capped Ag-nanoclusters. The bioassay permits discriminating homocysteine from cysteine, glutathione and other amino acids, and allows sensitive and selective detection of homocysteine with a detection limit of 42 nM.

Graphical abstract: A sensitive and selective resonance light scattering bioassay for homocysteine in biological fluids based on target-involved assembly of polyethyleneimine-capped Ag-nanoclusters

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Article information

DOI
https://doi.org/10.1039/C0CC04463F
Article type
Communication
Submitted
17 Oct 2010
Accepted
12 Jan 2011
First published
02 Feb 2011

Chem. Commun., 2011,47, 3817-3819

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A sensitive and selective resonance light scattering bioassay for homocysteine in biological fluids based on target-involved assembly of polyethyleneimine-capped Ag-nanoclusters

S. Sun, H. Wang and X. Yan, Chem. Commun., 2011, 47, 3817 DOI: 10.1039/C0CC04463F

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