Issue 8, 2011
From the journal:

Chemical Communications

Chloride ion-catalyzed generation of difluorocarbene for efficient preparation of gem-difluorinated cyclopropenes and cyclopropanes†

Fei Wang,a   Wei Zhang,a   Jieming Zhu,a   Huaifeng Li,b   Kuo-Wei Huang*b  and  Jinbo Hu*a  

* Corresponding authors

a Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China
E-mail: jinbohu@sioc.ac.cn

b KAUST Catalysis Center and Division of Chemical and Life Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
E-mail: hkw@kaust.edu.sa

Abstract

A chloride ion-catalyzed generation of difluorocarbene from a relatively non-toxic and inexpensive precursor, Me3SiCF2Cl (1), under mild and neutral conditions leads to an efficient preparation of gem-difluorocyclopropenes and difluorocyclopropanes through [2 + 1] cycloaddition reactions with alkynes and alkenes, respectively.

Graphical abstract: Chloride ion-catalyzed generation of difluorocarbene for efficient preparation of gem-difluorinated cyclopropenes and cyclopropanes

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Article information

DOI
https://doi.org/10.1039/C0CC04548A
Article type
Communication
Submitted
21 Oct 2010
Accepted
23 Nov 2010
First published
20 Dec 2010

Chem. Commun., 2011,47, 2411-2413

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Chloride ion-catalyzed generation of difluorocarbene for efficient preparation of gem-difluorinated cyclopropenes and cyclopropanes

F. Wang, W. Zhang, J. Zhu, H. Li, K. Huang and J. Hu, Chem. Commun., 2011, 47, 2411 DOI: 10.1039/C0CC04548A

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