Issue 11, 2011
From the journal:

Chemical Communications

Concurrent oxidations with tandem biocatalysts in one pot: green, selective and clean oxidations of methylene groups to ketones†

Wei Zhang,ab   Weng Lin Tang,a   Daniel I. C. Wangbc  and  Zhi Li*ab  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576
E-mail: chelz@nus.edu.sg
Fax: +65 6779 1936
Tel: +65 6516 8416

b Singapore-MIT Alliance, 4 Engineering Drive 3, Singapore 117576

c Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, USA

Abstract

A novel tandem-biocatalysts system consisting of a monooxygenase-containing microorganism and an alcohol dehydrogenase is developed for the concurrent oxidations of methylene groups to ketones in one pot, providing green, clean and simple access to valuable ketones with high yield, excellent selectivity and efficient cofactor recycling.

Graphical abstract: Concurrent oxidations with tandem biocatalysts in one pot: green, selective and clean oxidations of methylene groups to ketones

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Article information

DOI
https://doi.org/10.1039/C0CC04706F
Article type
Communication
Submitted
30 Oct 2010
Accepted
08 Jan 2011
First published
01 Feb 2011

Chem. Commun., 2011,47, 3284-3286

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Concurrent oxidations with tandem biocatalysts in one pot: green, selective and clean oxidations of methylene groups to ketones

W. Zhang, W. L. Tang, D. I. C. Wang and Z. Li, Chem. Commun., 2011, 47, 3284 DOI: 10.1039/C0CC04706F

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