PET imaging of nobiletin based on a practical total synthesis

Tomohiro Asakawa; Aiki Hiza; Miho Nakayama; Makoto Inai; Dai Oyama; Hiroyuki Koide; Kosuke Shimizu; Toshiyuki Wakimoto; Norihiro Harada; Hideo Tsukada; Naoto Oku; Toshiyuki Kan

doi:10.1039/C0CC04936K

PET imaging of nobiletin based on a practical total synthesis†

Tomohiro Asakawa,^a Aiki Hiza,^a Miho Nakayama,^a Makoto Inai,^a Dai Oyama,^a Hiroyuki Koide,^a Kosuke Shimizu,^a Toshiyuki Wakimoto,‡^a Norihiro Harada,^b Hideo Tsukada,^b Naoto Oku^a and Toshiyuki Kan*^a

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^a School of Pharmaceutical Sciences, University of Shizuoka and Global COE Program, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan
E-mail: kant@u-shizuoka-ken.ac.jp
Fax: +81 54-264-5745
Tel: +81 54-264-5746

^b Central Research Laboratory, Hamamatsu Photonics K. K., 5000 Hirakuchi, Hamakita-ku, Hamamatsu-shi, Shizuoka 434-8601, Japan

Abstract

A practical synthesis of nobiletin, a polymethoxylated citrus flavone, was accomplished by utilizing our novel flavone synthesis. Synthetic nobiletin was labelled by selective demethylation and rapid incorporation of ¹¹C atom. Positron emission tomography images successfully visualized the brain distribution, which may provide therapeutic benefits in the treatment of Alzheimer's disease.

Chemical Communications

PET imaging of nobiletin based on a practical total synthesis†

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PET imaging of nobiletin based on a practical total synthesis

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