Issue 12, 2011
From the journal:

Chemical Communications

Rapidly disassembling nanomicelles with disulfide-linked PEG shells for glutathione-mediated intracellular drug delivery†

Hui-Yun Wen,a   Hai-Qing Dong,a   Wen-juan Xie,a   Yong-Yong Li,*a   Kang Wang,a   Giovanni M. Paulettic  and  Dong-Lu Shi*ab  

* Corresponding authors

a The Institute for Advanced Materials and Nano Biomedicine, Tongji University, Shanghai 200092, China
E-mail: yongyong_li@tongji.edu.cn

b Department of Chemical and Materials Engineering, University of Cincinnati, Cincinnati, USA
E-mail: shid@ucmail.uc.edu

c James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, USA

Abstract

The synthesis and biological efficacy of novel nanomicelles that rapidly disassemble and release their encapsulated payload intracellularly under tumor-relevant glutathione (GSH) levels are reported. The unique design includes a PEG-sheddable shell and poly(ε-benzyloxycarbonyl-L-lysine) core with a redox-sensitive disulfide linkage.

Graphical abstract: Rapidly disassembling nanomicelles with disulfide-linked PEG shells for glutathione-mediated intracellular drug delivery

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Article information

DOI
https://doi.org/10.1039/C0CC04983B
Article type
Communication
Submitted
16 Nov 2010
Accepted
27 Jan 2011
First published
16 Feb 2011

Chem. Commun., 2011,47, 3550-3552

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Rapidly disassembling nanomicelles with disulfide-linked PEG shells for glutathione-mediated intracellular drug delivery

H. Wen, H. Dong, W. Xie, Y. Li, K. Wang, G. M. Pauletti and D. Shi, Chem. Commun., 2011, 47, 3550 DOI: 10.1039/C0CC04983B

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