Issue 11, 2011
From the journal:

Chemical Communications

Label-free detection of telomerase activity in HeLa cells using electrochemical impedance spectroscopy†

Weiqiang Yang,a   Xi Zhu,a   Qida Liu,b   Zhenyu Lin,*a   Bin Qiua  and  Guonan Chen*a  

* Corresponding authors

a Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, Fuzhou University, Fuzhou, Fujian, China
E-mail: zylin@fzu.edu.cn, gnchen@fzu.edu.cn
Fax: (+86)-591-22866135

b MOE Key Laboratory for Strength and Vibration, Xi'an Jiaotong University, Xi’an, Shaanxi, China

Abstract

A simple assay based on electrochemical impedance spectroscopy (EIS) for detection of telomerase activity is developed, and it is demonstrated that the label-free EIS method is capable of detecting the telomerase activity in HeLa cells with a detection limit of 1000 HeLa cells without using any amplification technique.

Graphical abstract: Label-free detection of telomerase activity in HeLa cells using electrochemical impedance spectroscopy

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Article information

DOI
https://doi.org/10.1039/C0CC05230B
Article type
Communication
Submitted
28 Nov 2010
Accepted
05 Jan 2011
First published
25 Jan 2011

Chem. Commun., 2011,47, 3129-3131

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Label-free detection of telomerase activity in HeLa cells using electrochemical impedance spectroscopy

W. Yang, X. Zhu, Q. Liu, Z. Lin, B. Qiu and G. Chen, Chem. Commun., 2011, 47, 3129 DOI: 10.1039/C0CC05230B

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