Issue 11, 2011
From the journal:

Chemical Communications

Phosphate mediated biomimetic synthesis of tetrahydroisoquinoline alkaloids†

Thomas Pesnot,a   Markus C. Gershater,b   John M. Wardb  and  Helen C. Hailes*a  

* Corresponding authors

a Department of Chemistry, University College London, 20 Gordon Street, London, UK
E-mail: h.c.hailes@ucl.ac.uk
Fax: +44 (0)20 7679 7463
Tel: +44 (0)20 7679 7463

b Research Department of Structural & Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK

Abstract

A one-pot synthesis of tetrahydroisoquinoline alkaloids in a phosphate buffer has been achieved, and a reaction mechanism proposed. The utilisation of mild reaction conditions readily afforded a range of isoquinolines, including norcoclaurine.

Graphical abstract: Phosphate mediated biomimetic synthesis of tetrahydroisoquinoline alkaloids

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Article information

DOI
https://doi.org/10.1039/C0CC05282E
Article type
Communication
Submitted
30 Nov 2010
Accepted
10 Jan 2011
First published
26 Jan 2011

Chem. Commun., 2011,47, 3242-3244

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Phosphate mediated biomimetic synthesis of tetrahydroisoquinoline alkaloids

T. Pesnot, M. C. Gershater, J. M. Ward and H. C. Hailes, Chem. Commun., 2011, 47, 3242 DOI: 10.1039/C0CC05282E

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