We present a novel approach for single DNA molecule analysis using neutravidin coated surfaces. DNA molecules are elongated and reversibly immobilized on neutravidin coated surfaces with pH and salt controls. We demonstrate restriction enzyme reactions for optical mapping and ligation for tethered DNA molecules.
Y. Kim and K. Jo, Chem. Commun., 2011, 47, 6248 DOI: 10.1039/C0CC05396A
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