Issue 10, 2011
From the journal:

Chemical Communications

Paper spray ionization of polar analytes using non-polar solvents†

Anyin Li,a   He Wang,b   Zheng Ouyangb  and  R. Graham Cooks*a  

* Corresponding authors

a Department of Chemistry and Center for Analytical Instrumentation Development, 560 Oval Drive, Purdue University, West Lafayette, USA
E-mail: cooks@purdue.edu
Fax: +1 (0)765 494 9421
Tel: +1 (0)765 494 5263

b Weldon School of Biomedical Engineering, Purdue University, 206 South Intramural Drive, West Lafayette, USA
E-mail: ouyang@purdue.edu
Fax: +1 (0)765 496 1912
Tel: +1 (0)765 494 2214

Abstract

Non-polar solvents like hexane allow ionization of insoluble drugs, peptides, nucleotides and phospholipids as solids from paper. Ambient ionization is achieved simply by application of a high voltage to the wet paper. Transport and ionization mechanisms are discussed, including the possibility of field desorption from dendritic structures formed on the paper.

Graphical abstract: Paper spray ionization of polar analytes using non-polar solvents

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Article information

DOI
https://doi.org/10.1039/C0CC05513A
Article type
Communication
Submitted
11 Dec 2010
Accepted
19 Jan 2011
First published
01 Feb 2011

Chem. Commun., 2011,47, 2811-2813

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Paper spray ionization of polar analytes using non-polar solvents

A. Li, H. Wang, Z. Ouyang and R. G. Cooks, Chem. Commun., 2011, 47, 2811 DOI: 10.1039/C0CC05513A

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