Issue 15, 2011
From the journal:

Chemical Communications

pH-Sensitive brush polymer-drug conjugates by ring-opening metathesis copolymerization†

Jiong Zou,a   Goran Jafr,b   Efrosyni Themistou,a   Yoonsing Yap,a   Zachary A. P. Wintrob,b   Paschalis Alexandridis,a   Alice C. Ceacareanub  and  Chong Cheng*a  

* Corresponding authors

a Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA
E-mail: ccheng8@buffalo.edu

b Department of Pharmacy Practice, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA

Abstract

Representing a new category of polymer-drug conjugates, brush polymer-drug conjugates were prepared by ring-opening metathesis copolymerization. Following judicious structural design, these conjugates exhibited well-shielded drug moieties, significant water solubility, well-defined nanostructures, and acid-triggered drug release.

Graphical abstract: pH-Sensitive brush polymer-drug conjugates by ring-opening metathesis copolymerization

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Article information

DOI
https://doi.org/10.1039/C0CC05531J
Article type
Communication
Submitted
13 Dec 2010
Accepted
23 Feb 2011
First published
11 Mar 2011

Chem. Commun., 2011,47, 4493-4495

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pH-Sensitive brush polymer-drug conjugates by ring-opening metathesis copolymerization

J. Zou, G. Jafr, E. Themistou, Y. Yap, Z. A. P. Wintrob, P. Alexandridis, A. C. Ceacareanu and C. Cheng, Chem. Commun., 2011, 47, 4493 DOI: 10.1039/C0CC05531J

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