Issue 21, 2011
From the journal:

Chemical Communications

Cholinedendrimers as generic scaffolds for the non-covalent synthesis of multivalent proteinassemblies†

Víctor M. Hernández-Rocamora,‡a   Sanne W. A. Reulen,b   Bas de Waal,b   E. W. Meijer,b   Jesus M. Sanza  and  Maarten Merkx*b  

* Corresponding authors

a Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Avda Universidad s/n, Elche 03202, Spain
E-mail: jmsanz@umh.es
Fax: +34 966658758
Tel: +34 966658460

b Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
E-mail: m.merkx@tue.nl
Fax: +31 402451036
Tel: +31 402474728

Abstract

A modular self-assembly strategy is presented that allows the non-covalent synthesis of multivalent protein dendrimers using the strong interaction between choline-functionalized dendrimers and the choline binding protein C-LytA. Choline dendrimers displaying fusion proteins of C-LytA and the collagen binding protein CNA35 represent attractive multivalent targeting ligands for collagen imaging.

Graphical abstract: Choline dendrimers as generic scaffolds for the non-covalent synthesis of multivalent protein assemblies

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Article information

DOI
https://doi.org/10.1039/C0CC05605G
Article type
Communication
Submitted
15 Dec 2010
Accepted
05 Apr 2011
First published
21 Apr 2011

Chem. Commun., 2011,47, 5997-5999

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Choline dendrimers as generic scaffolds for the non-covalent synthesis of multivalent protein assemblies

V. M. Hernández-Rocamora, S. W. A. Reulen, B. de Waal, E. W. Meijer, J. M. Sanz and M. Merkx, Chem. Commun., 2011, 47, 5997 DOI: 10.1039/C0CC05605G

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