Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical

Fumiya Mito; Toshihide Yamasaki; Yuko Ito; Mayumi Yamato; Hiroyuki Mino; Hiromi Sadasue; Chisato Shirahama; Kiyoshi Sakai; Hideo Utsumi; Ken-ichi Yamada

doi:10.1039/C0CC05764A

Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical†

Fumiya Mito,^a Toshihide Yamasaki,^a Yuko Ito,^a Mayumi Yamato,^b Hiroyuki Mino,^c Hiromi Sadasue,^a Chisato Shirahama,^a Kiyoshi Sakai,^b Hideo Utsumi^b and Ken-ichi Yamada*^a

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^a Department of Bio-functional Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan
E-mail: yamada@pch.phar.kyushu-u.ac.jp
Fax: +81-92-642-6626
Tel: +81-92-642-6624

^b Innovation Center for Medical Redox Navigation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan

^c Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Japan

Abstract

Amyloid nitroxyl radical (nitroxide) ligands were used to detect amyloid-β fibrils, the main constituents of senile plaques in Alzheimer's disease, using anisotropic ESR spectra, and were found to affect the aggregation process due to the radical functionality. These compounds have great potential as novel and multifunctional probes, combining spin labels, spin probes, and fluorescence probes.

Chemical Communications

Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical†

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Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical

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