Issue 10, 2011
From the journal:

Chemical Communications

Thermodynamic stability of Hoogsteen and Watson–Crick base pairs in the presence of histone H3-mimicking peptide†

Smritimoy Pramanik,a   Kaori Nakamura,a   Kenji Usui,ab   Shu-ichi Nakano,ab   Sarika Saxena,a   Jun Matsui,ab   Daisuke Miyoshi*ab  and  Naoki Sugimoto*ab  

* Corresponding authors

a Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Japan
E-mail: miyoshi@center.konan-u.ac.jp, sugimoto@konan-u.ac.jp
Fax: +81 78 303 1495
Tel: +81 78 303 1426

b Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Japan

Abstract

We found that Hoogsteen base pairs were stabilized by molecular crowding and a histone H3-mimicking peptide, which was not observed for Watson–Crick base pairs. Our findings demonstrate that the type of DNA base pair is critical for the interaction between DNA and histones.

Graphical abstract: Thermodynamic stability of Hoogsteen and Watson–Crick base pairs in the presence of histone H3-mimicking peptide

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Article information

DOI
https://doi.org/10.1039/C0CC05776B
Article type
Communication
Submitted
24 Dec 2010
Accepted
18 Jan 2011
First published
09 Feb 2011

Chem. Commun., 2011,47, 2790-2792

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Thermodynamic stability of Hoogsteen and Watson–Crick base pairs in the presence of histone H3-mimicking peptide

S. Pramanik, K. Nakamura, K. Usui, S. Nakano, S. Saxena, J. Matsui, D. Miyoshi and N. Sugimoto, Chem. Commun., 2011, 47, 2790 DOI: 10.1039/C0CC05776B

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