Issue 17, 2011
From the journal:

Chemical Communications

Benzothiazole-substituted benzofuroquinolinium dye: a selective switch-on fluorescent probe for G-quadruplex†

Yu-Jing Lu,a   Siu-Cheong Yan,a   Fung-Yi Chan,a   Lan Zou,a   Wai-Hong Chung,a   Wing-Leung Wong,a   Bin Qiu,a   Ning Sun,a   Pak-Ho Chan,a   Zhi-Shu Huang,b   Lian-Quan Gub  and  Kwok-Yin Wong*a  

* Corresponding authors

a Department of Applied Biology and Chemical Technology and the Institute of Molecular Technology for Drug Synthesis and Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
E-mail: bckywong@polyu.edu.hk
Fax: +852 2364 9932

b School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510080, China

Abstract

A new switch-on fluorescent probe containing the natural product cryptolepine analogue benzofuroquinolinium moiety (binding scaffold) and a benzothiazole moiety (signalling unit) shows a remarkable fluorescence enhancement selective for the G-quadruplex nucleic acid structure. Binding studies revealed that the highly selective response of the fluorescent probe arises from end-stack binding to G-quadruplex.

Graphical abstract: Benzothiazole-substituted benzofuroquinolinium dye: a selective switch-on fluorescent probe for G-quadruplex

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Article information

DOI
https://doi.org/10.1039/C1CC00020A
Article type
Communication
Submitted
03 Jan 2011
Accepted
09 Mar 2011
First published
23 Mar 2011

Chem. Commun., 2011,47, 4971-4973

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Benzothiazole-substituted benzofuroquinolinium dye: a selective switch-on fluorescent probe for G-quadruplex

Y. Lu, S. Yan, F. Chan, L. Zou, W. Chung, W. Wong, B. Qiu, N. Sun, P. Chan, Z. Huang, L. Gu and K. Wong, Chem. Commun., 2011, 47, 4971 DOI: 10.1039/C1CC00020A

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