Issue 18, 2011
From the journal:

Chemical Communications

Hexanuclear self-assembled arene-ruthenium nano-prismatic cages: potential anticancer agents†

Vaishali Vajpayee,a   Yoon Jung Yang,b   Se Chan Kang,*b   Hyunuk Kim,c   In Su Kim,a   Ming Wang,d   Peter J. Stang*d  and  Ki-Whan Chi*a  

* Corresponding authors

a Department of Chemistry, University of Ulsan, Ulsan 680-749, Republic of Korea
E-mail: kwchi@ulsan.ac.kr

b Department of Natural Medicine Resources, University of Semyung, Jecheon 390-711, Republic of Korea
E-mail: sckang@semyung.ac.kr

c Department of Chemistry, POSTECH, Pohang 690-784, Republic of Korea

d Department of Chemistry, University of Utah, Salt Lake City, Utah 84112-0850, USA
E-mail: stang@chem.utah.edu

Abstract

Two novel nano-cage compounds, 8 and 9, were prepared by self-assembly of the ruthenium complexes 4 and 5, and the tripodal donor 1. The cytotoxicity of 8 was found to be considerably stronger than that of cisplatin. The complex 8 inhibited tumor cell proliferation by interfering into regulatory pathways of the cell cycleviaapoptosis.

Graphical abstract: Hexanuclear self-assembled arene-ruthenium nano-prismatic cages: potential anticancer agents

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Article information

DOI
https://doi.org/10.1039/C1CC10167F
Article type
Communication
Submitted
10 Jan 2011
Accepted
14 Mar 2011
First published
30 Mar 2011

Chem. Commun., 2011,47, 5184-5186

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Hexanuclear self-assembled arene-ruthenium nano-prismatic cages: potential anticancer agents

V. Vajpayee, Y. J. Yang, S. C. Kang, H. Kim, I. S. Kim, M. Wang, P. J. Stang and K. Chi, Chem. Commun., 2011, 47, 5184 DOI: 10.1039/C1CC10167F

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