Issue 16, 2011
From the journal:

Chemical Communications

Gadolinium-doped LipoCEST agents: a potential novel class of dual 1H-MRI probes†

Enzo Terreno,*a   Cinzia Boffa,a   Valeria Menchise,b   Franco Fedeli,c   Carla Carrera,c   Daniela Delli Castelli,a   Giuseppe Digiliod  and  Silvio Aimea  

* Corresponding authors

a Department of Chemistry IFM and Molecular & Preclinical Imaging Centres, University of Torino, via Nizza 52, Torino, Italy
E-mail: enzo.terreno@unito.it
Fax: +39 011-6706487
Tel: +39 011-6706452

b Institute for Biostructures and Bioimages (CNR), c/o Molecular Biotechnology Center, University of Torino, via Nizza 52, Torino, Italy

c Laboratory of Integrated and Advanced Methodologies, Bioindustry Park of Canavese, via Ribes, 5, Colleretto Giacosa (TO), Italy

d Department of Life and Environmental Sciences, University of Eastern Piedmont “A. Avogadro”, Alessandria, Italy

Abstract

A novel class of paramagnetic liposome-based systems acting as dual T1 and CEST 1H-MRI contrast agents is described. The vesicles contain a shift reagent in the aqueous core and a Gd-complex on the external surface conjugated through a biodegradable linker. As such, the probe can generate T1 contrast only, but after the cleavage and removal of the Gd-coating, the CEST contrast is switched on.

Graphical abstract: Gadolinium-doped LipoCEST agents: a potential novel class of dual 1H-MRI probes

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1CC10172B
Article type
Communication
Submitted
10 Jan 2011
Accepted
22 Feb 2011
First published
15 Mar 2011

Chem. Commun., 2011,47, 4667-4669

Permissions

Request permissions

Gadolinium-doped LipoCEST agents: a potential novel class of dual 1H-MRI probes

E. Terreno, C. Boffa, V. Menchise, F. Fedeli, C. Carrera, D. D. Castelli, G. Digilio and S. Aime, Chem. Commun., 2011, 47, 4667 DOI: 10.1039/C1CC10172B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements