DNA-based switches are currently operated by manual solution-phase addition of ‘set-strands’. We demonstrate another operation method—sterically inaccessible ‘set-strands’, released from a surface into solution by spatially controlled photocleavage. This technique will enable microarrays of set-strands to operate many DNA-based switches in self-contained computational and diagnostic devices.
A. K. Mok, N. A. Kedzierski, P. N. Chung and P. S. Lukeman, Chem. Commun., 2011, 47, 4905 DOI: 10.1039/C1CC10292C
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