Issue 15, 2011
From the journal:

Chemical Communications

Controllable exploding microcapsules as drug carriers†

Jing Zhang,a   Cao Li,a   Ya Wang,a   Ren-Xi Zhuoa  and  Xian-Zheng Zhang*a  

* Corresponding authors

a Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, P. R. China
E-mail: xz-zhang@whu.edu.cn
Fax: +86-27-6875 4509
Tel: +86-27-6875 4061

Abstract

Controllable exploding polyelectrolyte microcapsules were developed by layer-by-layer assembly of poly(allylamine hydrochloride) (PAH) and poly(sodium 4-styrenesulfonate) (PSS) on a dextran microgel core containing a cleavable disulfide bond fabricated via click chemistry. The microcapsules can explode upon the injection of DTT with an explosive release of the drug.

Graphical abstract: Controllable exploding microcapsules as drug carriers

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Article information

DOI
https://doi.org/10.1039/C1CC10337G
Article type
Communication
Submitted
18 Jan 2011
Accepted
22 Feb 2011
First published
09 Mar 2011

Chem. Commun., 2011,47, 4457-4459

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Controllable exploding microcapsules as drug carriers

J. Zhang, C. Li, Y. Wang, R. Zhuo and X. Zhang, Chem. Commun., 2011, 47, 4457 DOI: 10.1039/C1CC10337G

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