Issue 29, 2011
From the journal:

Chemical Communications

Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor†

Fabien W. Monnard,a   Tillmann Heinisch,ab   Elisa S. Nogueira,a   Tilman Schirmerb  and  Thomas R. Ward*a  

* Corresponding authors

a Department of Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland
E-mail: thomas.ward@unibas.ch
Fax: +41 61 267 10 05
Tel: +41 61 267 10 04

b Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland
E-mail: tilman.schirmer@unibas.ch
Fax: +41 61 267 21 09
Tel: +41 61 267 20 89

Abstract

d6-piano-stool complexes bearing an arylsulfonamide anchor display sub-micromolar affinity towards human Carbonic Anhydrase II (hCA II). The 1.3 Å resolution X-ray crystal structure of [(η6-C6Me6)Ru(bispy 3)Cl]+ ⊂ hCA II highlights the nature of the host–guest interactions.

Graphical abstract: Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1CC10345H
Article type
Communication
Submitted
18 Jan 2011
Accepted
08 Jun 2011
First published
27 Jun 2011

Chem. Commun., 2011,47, 8238-8240

Permissions

Request permissions

Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor

F. W. Monnard, T. Heinisch, E. S. Nogueira, T. Schirmer and T. R. Ward, Chem. Commun., 2011, 47, 8238 DOI: 10.1039/C1CC10345H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements