Issue 16, 2011
From the journal:

Chemical Communications

Small-molecule fluorescent probes for specific RNA targets†

Asako Murata,‡a   Shin-ichi Sato,‡a   Yoshinori Kawazoeb  and  Motonari Uesugi*ab  

* Corresponding authors

a Institute for Integrated Cell-Material Sciences, Kyoto University Gokasho, Uji, Kyoto 611-0011, Japan
E-mail: uesugi@scl.kyoto-u.ac.jp
Fax: +81 (0)774-38-3226
Tel: +81 (0)774-38-3225

b Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan

Abstract

A method was developed that uses small molecules as fluorescent probes to detect specific mRNAs. In this approach, the fluorescence of fluorophore–quencher conjugates is restored by the binding of an mRNA aptamer tag to the quencher segment of the molecules. The method allows real-time detection of mRNA transcripts in vitro.

Graphical abstract: Small-molecule fluorescent probes for specific RNA targets

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Article information

DOI
https://doi.org/10.1039/C1CC10393H
Article type
Communication
Submitted
20 Jan 2011
Accepted
25 Feb 2011
First published
17 Mar 2011

Chem. Commun., 2011,47, 4712-4714

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Small-molecule fluorescent probes for specific RNA targets

A. Murata, S. Sato, Y. Kawazoe and M. Uesugi, Chem. Commun., 2011, 47, 4712 DOI: 10.1039/C1CC10393H

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