Issue 20, 2011
From the journal:

Chemical Communications

Caged molecular beacons: controlling nucleic acid hybridization with light†

Chunming Wang,‡a   Zhi Zhu,‡bc   Yanling Song,a   Hui Lin,a   Chaoyong James Yang*a  and  Weihong Tan*bc  

* Corresponding authors

a State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
E-mail: cyyang@xmu.edu.cn

b State Key Laboratory of Chemo/Biosensing and Chemometrics College of Biology and College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China
E-mail: tan@chem.ufl.edu

c Department of Chemistry and Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida 32611-7200, USA
E-mail: tan@chem.ufl.edu

Abstract

We have constructed a novel class of light-activatable caged molecular beacons (cMBs) that are caged by locking two stems with a photo-labile biomolecular interaction or covalent bond. With the cMBs, the nucleic acid hybridization process can be easily controlled with light, which offers the possibility for a high spatiotemporal resolution study of intracellular mRNAs.

Graphical abstract: Caged molecular beacons: controlling nucleic acid hybridization with light

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Article information

DOI
https://doi.org/10.1039/C1CC10481K
Article type
Communication
Submitted
24 Jan 2011
Accepted
04 Apr 2011
First published
18 Apr 2011

Chem. Commun., 2011,47, 5708-5710

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Caged molecular beacons: controlling nucleic acid hybridization with light

C. Wang, Z. Zhu, Y. Song, H. Lin, C. J. Yang and W. Tan, Chem. Commun., 2011, 47, 5708 DOI: 10.1039/C1CC10481K

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