Issue 17, 2011
From the journal:

Chemical Communications

A facile, metal- and solvent-free, autoxidative coupling of quinolines with indoles and pyrroles†

Mikaël Brasse,a   Jonathan A. Ellman*c  and  Robert G. Bergman*ab  

* Corresponding authors

a Department of Chemistry, University of California, Berkeley, California 94720, USA

b Division of Chemical Sciences Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
E-mail: rbergman@berkeley.edu

c Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA
E-mail: jonathan.ellman@yale.edu

Abstract

A simple, solvent-free, one-pot autoxidative coupling reaction between quinoline and indoles or pyrroles is reported. This atom economic method requires only a stoichiometric amount of inexpensive hydrochloric acid and does not require a catalyst.

Graphical abstract: A facile, metal- and solvent-free, autoxidative coupling of quinolines with indoles and pyrroles

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Article information

DOI
https://doi.org/10.1039/C1CC10507H
Article type
Communication
Submitted
25 Jan 2011
Accepted
18 Feb 2011
First published
29 Mar 2011

Chem. Commun., 2011,47, 5019-5021

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A facile, metal- and solvent-free, autoxidative coupling of quinolines with indoles and pyrroles

M. Brasse, J. A. Ellman and R. G. Bergman, Chem. Commun., 2011, 47, 5019 DOI: 10.1039/C1CC10507H

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