Organophosphorus acid anhydrolase bio-template for the synthesis of CdS quantum dots

Liang Zhao; Kerim M. Gattás-Asfura; Jianmin Xu; Ravi A. Patel; Anup Dadlani; Myrna Sillero-Mahinay; Marie Cushmore; Vipin K. Rastogi; Saumil S. Shah; Roger M. Leblanc

doi:10.1039/C1CC10714C

Organophosphorus acid anhydrolase bio-template for the synthesis of CdS quantum dots†

Liang Zhao,^a Kerim M. Gattás-Asfura,^a Jianmin Xu,^a Ravi A. Patel,^a Anup Dadlani,^a Myrna Sillero-Mahinay,^b Marie Cushmore,^a Vipin K. Rastogi,^c Saumil S. Shah^d and Roger M. Leblanc*^a

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* Corresponding authors

^a The Department of Chemistry, University of Miami, Coral Gables, USA
E-mail: rml@miami.edu
Fax: (305) 284-4571
Tel: (305) 284-2194

^b The Department of Chemistry, MSU-Iligan Institute of Technology, Iligan City

^c BioDefense Team, R&T Directorate, US Army-ECBC, AMSRD-ECB-RT-BD, APG, USA

^d Biochemistry Team, Edgewood, USA

Abstract

A direct conjugation of organophosphorus acid anhydrolase (OPAA) with CdS quantum dots was prepared via arrested precipitation within the enzyme matrix. The bio-conjugate was found not only to retain enzyme conformational structure but also to retain enzyme activity and be effective at detecting diisopropyl fluorophosphate (DFP) at the micro molar level.

Chemical Communications

Organophosphorus acid anhydrolase bio-template for the synthesis of CdS quantum dots†

Abstract

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Organophosphorus acid anhydrolase bio-template for the synthesis of CdS quantum dots

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