Issue 17, 2011

A new three-component reaction: green synthesis of novel isoindolo[2,1-a]quinazoline derivatives as potent inhibitors of TNF-α

Abstract

Concurrent construction of five and six membered fused N-heretocyclic ring was achieved via a conceptually new three-component reaction affording 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-diones as novel inhibitors of TNF-α in vitro. This represents one of the few examples of direct TNF-α inhibition by small molecules.

Graphical abstract: A new three-component reaction: green synthesis of novel isoindolo[2,1-a]quinazoline derivatives as potent inhibitors of TNF-α

Supplementary files

Article information

Article type
Communication
Submitted
06 Feb 2011
Accepted
09 Mar 2011
First published
29 Mar 2011

Chem. Commun., 2011,47, 5010-5012

A new three-component reaction: green synthesis of novel isoindolo[2,1-a]quinazoline derivatives as potent inhibitors of TNF-α

K. S. Kumar, P. M. Kumar, K. A. Kumar, M. Sreenivasulu, A. A. Jafar, D. Rambabu, G. R. Krishna, C. M. Reddy, R. Kapavarapu, K. Shivakumar, K. K. Priya, K. V. L. Parsa and M. Pal, Chem. Commun., 2011, 47, 5010 DOI: 10.1039/C1CC10715A

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