Synthesis of Pt@Fe2O3 nanorods as MRI probes for in vivo application

Yonggang Li; Yinjie Lu; Haiyan Hong; Yinyin Chen; Xinxing Ma; Liang Guo; Zhongling Wang; Jianhua Chen; Mo Zhu; Jiankun Ni; Hongwei Gu; Jianmei Lu; Jackie Y. Ying

doi:10.1039/C1CC10758E

Synthesis of Pt@Fe₂O₃nanorods as MRI probes for in vivo application†

Yonggang Li,^a Yinjie Lu,^b Haiyan Hong,^b Yinyin Chen,^a Xinxing Ma,^a Liang Guo,*^a Zhongling Wang,^a Jianhua Chen,^a Mo Zhu,^a Jiankun Ni,^c Hongwei Gu,*^b Jianmei Lu*^b and Jackie Y. Ying*^d

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* Corresponding authors

^a Department of Radiology, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China
E-mail: ilguoliang@sohu.com

^b Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemical, Chemical Engineering and Materials Science, Soochow University, Suzhou, China
E-mail: hongwei@suda.edu.cn
Fax: +86-65880905
Tel: +86-65880905

^c Department of Radiology, the First People Hospital of Wujiang City, Wujiang, China

^d Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669

Abstract

Magnetic Fe₂O₃ nanorods with low cell toxicity were successfully synthesized via a wet-chemical method. In vivo studies with a rabbit model show that the nanorods exhibit excellent T₂ signal enhancement. This work demonstrates that magnetic nanorods may provide a new type of MR enhancement agent for use in biomedical applications.

Chemical Communications

Synthesis of Pt@Fe₂O₃nanorods as MRI probes for in vivo application†

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Synthesis of Pt@Fe₂O₃ nanorods as MRI probes for in vivo application

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